Clinical Studies & Research

Dr. Cox recently completed work as principal investigator for the study “A Phase 3, Randomized, Double-Blind, Placebo Controlled, Multi-Center Trial to Evaluate the Efficacy and Safety of [product] for Injection to Treat Moderate to Severe Glabellar Lines”  This is another new, Botox-like product seeking registration for treatment of vertical lines between the eyebrows.  This is the third new product in as many years looking to displace market leader Botox in the treatment of facial lines.  Adding already registered Dysport and Xeomin to the mix means we’ll eventually have six (or more) injectables for treating facial lines.  Each of the products is unique in some way, and we’ve really enjoyed working with the manufacturers to identify which patients will most benefit from the characteristics of their product.  It’s an interesting time in aesthetic medicine!   This study began in November 2016 and just finished in December 2017.

Dr. Cox is serving as principal investigator in the study “Randomized Double Blind Phase 3 Study to Assess the Efficacy and Safety of [product] in the Treatment of Glabellar Lines in Comparison With Placebo Followed by an Open Label Extension Study.” This study is evaluating a new Botox-like product for treatment of vertical lines between the eyebrows.  We expect this will come to market in the next year or so.  As companies develop similar products with slightly different characteristics, there’s opportunity for skilled injectors to tailor treatments by selecting products best matched to an individual’s unique facial anatomy.  It’s customized aesthetic medicine and we’re excited about the possibilities.  The study began in October 2016 and is nearing completion.

Dr. Cox was a site clinician for the study “Qualitative Work on the Facial Lines Satisfaction Questionnaire (FLSQ) in Select Age Groups.”   This work continued the development of tools to assess patient satisfaction with treatment of facial lines.  In this case we applaud Allergan for supporting objective measurement of patient satisfaction.  Although we know the products work long before they come to market, the proof is whether patients agree once they’re out and in use.  The study was performed August through December 2016.

Dr. Cox was principal investigator in the study “A Multi-Center, Open Label, Multiple Dose, Phase II Trial to Demonstrate the Safety of [product] in Adult Subjects for Treatment of Moderate-to-Severe Glabellar Lines.”  This was a follow-up to an earlier study, evaluating multiple treatments in an unblinded study.  The product is coming to market soon, and when it arrives, the most experienced injector in the southeast will be right here in Chapel Hill!  Thank you to all the Triangle residents who helped us bring this exciting new Botox-like product to market.  The study was performed April 2014 to March 2017.

Dr. Cox was principal investigator for the study “A Multi-center, Randomized, Double-Blinded, Placebo-Controlled  Study Evaluating the Safety and Efficacy of [product] for the Reduction of Central Abdominal Bulging.”  This is the second study (different product) we’ve done evaluating an injectable treatment for belly fat.  We keep hoping one will come to market cause a few of us could use a little help !    The product has not been approved for this use, though we understand research on the molecule for injectable treatment of fat continues.  Stay tuned, we’ll keep you posted if we get any updates.  The study was performed April through August 2015.